Experience the ultimate effect with Long Lost Night Tablets in Pakistan. The natural physiological process of erection is supported by the parasympathetic nervous system, releasing nitric oxide (NO) into the Corpus cavernosum of the penis. This stimulates the enzyme guanylate cyclase, increasing levels of cyclic guanosine monophosphate (cGMP) and ultimately promoting smooth muscle relaxation (vasodilation). This leads to improved blood flow and a satisfying erection.
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum. the molecular structure of Sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 I=in the corpus cavernosum, resulting in more cGMP and better erections.
Dapoxetine works by mainly inhibiting the serotonin transporter's reuptake action. It has also been demonstrated to bind and inhibit the reuptake transporters of dopamine and norepinephrine.
Onset of action: 60 minutes | Duration: 2-4 hours | Absorption: Rapid, slower with high-fat meal | Distribution: Vdss: 105 L | Plasma protein binding: 96% | Metabolism: Hepatic via CYP3A4 (major) and CYP2C9 (minor) | Bioavailability: 40% | Elimination half-life: 4 hours | Time to Peak: 30-120 minutes (delayed by 60 minutes with a high-fat meal).
Long Lost Night Tablet Dapoxetine 60mg Tablet is rapidly absorbed and reaches peak plasma concentration (Tmaxx) within 1.4 to 2.0 hours after oral administration. Subsequently, there is a rapid decline in plasma concentration, with levels at about 5% of peak, which increases proportionately with doses up to 100 mg. The mean initial half-life of dapoxetine after a single dose is 0.5 to 0.8 hours, slightly decreasing to 0.4 to 0.6 hours after multiple doses for 6 days. Dapoxetine is metabolized in the liver to 2 metabolites, with a terminal half-life of 15 to 19 pairs after a single dose and 20 to 24 after multiple doses.
Dapoxetine treatment is not without major side effects, however, these include Nausea, Headache, Diarrhea, and Dizziness.
Take 1 Tablet 1 2 Hours before sexual intercourse with water
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